Natural rubber has a wide range of compatibility, and many compounding agents can be used for NR. The necessary coordination system for NR is a vulcanization system. The systems that are generally used in actual engineering are the aging protection system, the reinforcing filling system and the operating system. Sometimes special coordination systems are required, such as flame retardant, foaming, bonding, magnetic, conductive, high insulation, color, transparency, large density, and low density.

The most commonly used vulcanization system for NR is the sulfur vulcanization system, which includes: sulfur, accelerators, and active agents. Commonly used accelerators are thiazoles (such as sulfenamides (such as CZ), thiurams (such as TMTD), etc. Active agents mostly use zinc oxide and stearic acid. Peroxide, maleimide, phenolic Resins such as resins can also be sulphurized. The antioxidants mainly include amines such as 4020 and other p-phenylenediamines; non-polluting phenols such as 2246.

Reinforcement filling system can be used without, NR has good self-reinforcing property, but in order to further improve mechanical properties, improve processing performance and reduce cost, a reinforcing agent is generally used. Reinforcing agents are mainly carbon black and white carbon black, and are also reinforced with reinforcing resins and methacrylates. Commonly used fillers are calcium carbonate, clay, talc, etc.; organic such as wood flour, fruit shell powder; industrial waste such as powder ash. Operating aids include petroleum naphthenic oils, aromatic oils, and paraffin waxes. There are also coal tar, pine tar, Gumalon and so on.